Frederick J. Bollum Endowed Research Fund for Biochemistry Lectureship Series

The 10th Annual Bollum Symposium

Wednesday, May 7rd, 2008
1:00 - 5:00 pm
Coffman Theater

Invited Speakers

Dr. Steve A. Kay, University of California, San Diego
Dr. Amita Sehgal, HHMI/ University of Pennsylvania Medical School
Dr. Joseph S. Takahashi, HHMI/Northwestern University
Dr. Ying-Hui Fu, University of California, San Francisco

The Department of Biochemistry, Molecular Biology and Biophysics proudly present the 9 th Bollum Symposium entitled "Regulating Biological Function by Ubiquitination." Post-translational modification by the covalent attachment of ubiquitin regulates nearly every facet of biology including apoptosis, cell cycle control, and transcription. The symposium will feature four internationally renowned researchers who have made substantial contributions to the current understanding of biological regulation by ubiquitination. The featured speakers include Dr. Keith D. Wilkinson, Professor and Vice Chair of Biochemistry and Acting Director of the Graduate Division of Biological and Biomedical Sciences at Emory University, Dr. Rachel E. Klevit, Professor of Biochemistry at the University of Washington, Dr. Daniel Finley, Professor of Cell Biology at Harvard Medical School, and Dr Randy Y. Hampton, Professor of Biology at the University of California, San Diego.   Each speaker will focus on different facets of ubiquitin modification to provide a stimulating symposium that contains the latest knowledge in the field.

Background
Frederick J. Bollum received a B.A. in Zoology in 1949 and a Ph.D. in Physiological Chemistry in 1956 from the University of Minnesota. He went on to a Postdoctoral Fellowship at the Universtiy of Wisconsin and then took a position at Oak Ridge National Laboratory in Tennessee. Later, he became a Professor of Biochemistry at the University of Kentuchy Medical School, in Lexington, KY and then Chairman of Biochemistry at Uniformed Services University for the Health Sciences, Bethesda, MD. He then moved on to become President and CEO of Supertechs, Inc., Biotechnology Consultants. His major research interests were nucleic acid chemistry and enzymology, nucleotide metabolism, genetic aspects of biochemistry, immunological diversification and recombinant DNA, authoring more than 260 papers and three books.

Dr. Bollum regularly contributes to the Department of Biochemistry, Molecular Biology and Biophysics through the Minnesota Medical Foundation. His gifts have helped support lectures, research, graduate student awards and meeting opportunities and an annual symposium on cutting edge research topics.

Year/Topic	Speaker/Affiliation	Titles
1999 Transcription Factors & Metabolic Control	Gretchen J. Darlington, Baylor College of Medicine Steven A. Kliewer, Glaxo-Wellcome Research & Develoment Timothy S. Osborne, University of California, Irvine	The Role of C/EBP Proteins in Integratie Metabolism PPARs and PXR: Orphan Nuclear Receptors that Define Novel Hormone Signaling Pathways. Positive and Negative Regulation of Genes that Regulate Cholesterol Metabolism.
2000 G Protein-Coupled Signaling	Nigel Bunnett, University of California, San Francisco Linda Hicke, Northwestern University John Tesmer, University of Texas David Clapham, Harvard Medical School	How Proteases Talk to Cells:   A Comparison of Signaling by Proteases and Neuropeptides Role of Ubiquitin in Signaling Receptor Downregulation Effector Regulation by Heterotrimeric G   Proteins:   Lessons Learned from Adenyl Cyclase Protein Gated Potassium Channels
2001 Directed Evolution of Biomolecules & Functional Genomics	Dr. Jeremy Minshull, Maxygen Dr. Karl Dane Wittrup, Massachusetts Institute of Technology Dr. George Georgiou, University of Texas	Biological Diversity: From Nature and Beyond. Engineering Protein Recognition, Stability, and Expression by Yeast Display Functional Expression of Multidisulfide Proteins in Bacteria: Genetic, Biochemical, Structural Biology and Directed Evolution Strategies.
2002 Nature's Copier: the DNA Replication Machinery	Dr. Melvin DePamphilis, National Institute of Child Health and Human Development Dr. Bik-Kwoon Tye, Cornell University Dr. James Berger, University of California, Berkeley	The ORC Cycle: a Novel Mechanism for Regulating Eukaryotic DNA Replication Coordination of Genome Expression and DNA Replication in Proliferating Cells: The Multiple Roles of the MCM Proteins in Eukaryotes Toward a Structural Understanding of DNA Replication Initiation
2003 Structural Dymamics of Membrane Signal Transduction	Dr. Wayne Hubbell, Jules Stein Eye Institute, UCLA Dr. Lynmarie Thompson, University of Massachusetts, Amherst Dr. John Spudich, University of Texas, Houston Dr. David Farrens, Oregon Health and Science University	A nitroxide's view of rhodopsin structure, dynamics and activation Site-directed solid-state NMR probing transmembrane signaling mechanisms in bacterial chemoreceptors. Microbial rhodopsins: structure/function in ion transport and signaling. Conformational changes in G-protein coupled receptors: insights gained from site-directed fluorescence studies.
2004 Proteomics: Advancing Our Understanding of Biology	Michel Desjardins, Université de Montréal Tim Haystead,Duke University Medical Center Kathryn E. Howell University of Colorado School of Medicine, Denver Bradford W. Gibson Buck Institute of Aging Research	Proteomics Brings New Paradigms to Immunology Proteome Mining Drug and Target Discovery en Masse. New Insights into Golgi Function Through Proteomics The Mitochondrial Proteome, Neurodegenerative Disease and Aging
2005 Computational Biochemistry and Molecular Biology (program)	Dr. Eric D. Siggia, Rockefeller University in New York Dr. Peter D. Karp, Stanford Research Institute International (SRI), Palo Alto (CA) Dr. Michael A. Savageau, University California, Davis. Dr. Jiali Gao, University of Minnesota	Computation Approaches to Blastoderm Patterning in the Fly and its Evolution. Databases and Algorithms for Pathway Bioinformatics. System Design Principles and Construction of Gene Circuits Dynamics, Pathways, and Tunneling: A Computational Perspective of Enzyme Catalysis
2006 The Science of Aging (program)	Dr. Leonard P. Guarante, MIT, Boston Dr. Holly Van Remmen, University of Texas, San Antonio Dr. Richard A. Miller, University of Michigan Dr. Richard Weindruch, University of Wisconsin	SIR2, Calorie Restriction and Aging Fifty Years of the Oxidative Stress Theory of Aging: Where Are We Now? Fifty Years of the Oxidative Stress Theory of Aging: Where Are We Now? Size, Stress, and Aging: Lessons from Dwarf Mice Caloric Restriction and Aging: Studies in Mice and Monkeys
2007 Reguating Biological Function by Ubiquitination (program)	Dr. Rachel Klevit, University of Washington, Seattle, WA Dr. Keith D. Wilkinson, Emory University School of Medicine, Atlanta, GA Dr. Daniel Finley, Harvard Medical School, Boston, MA Dr. Randy Hampton, University of California, San Diego, La Jolla, CA	Recognition and Disassembly of the Polyubiquitin Targeting Signal. Structural Insights into Diversity and specificity in Protein Ubiquitination. Regulation of Protasome Activity. Protein Quality Control in Cell Regulation.
2008 Circadian Clocks (program)	Dr. Steve A. Kay, University of California, San Diego      Dr. Amita Sehgal, HHMI/ University of Pennsylvania Medical School      Dr. Joseph S. Takahashi, HHMI/Northwestern University Dr. Ying-Hui Fu, University of California, San Francisco	Network Discovery Pipelines for Circadian Clocks. Molecular Biology of Circadian Rhythms in Drosophila. Genetic Analysis of Circadian Clocks in Mammals. Molecular Characterization of Human Sleep Variants.